VDR and gemini ligands

VDR and gemini ligands.

The active form of vitamin D, 1α,25-dihydroxyvitamin D3 [1,25(OH) 2 D 3 ; calcitriol], plays a key role in mineral and bone homeostasis, and exerts potent anti-inflammatory and anti-proliferative activities [1]. It is thus a potential pharmacological agent to treat various diseases, including autoimmune disorders, infections and cancer [1]. However, the 1,25(OH) 2 D 3 doses required to elicit s...

Novel nonsecosteroidal VDR ligands with phenyl-pyrrolyl pentane skeleton for cancer therapy.

A series of nonsecosteroidal vitamin D3 receptor (VDR) ligands with phenyl-pyrrolyl pentane skeleton were synthesized for cancer therapy. In contrast to 1α,25-dihydroxyvitamin D3 (Calcitriol), these VDR ligands exhibited anti-proliferative activity without inducing hypercalcemia. These compounds were evaluated for vitamin D3-agonistic ability and anti-proliferative activity in vitro. Among them...

Regulation of ASBT (SLC10A2) by VDR, FXR and GR ligands in Rat and Human Ileum and Liver

Gemini - learning cooperative behaviors with - out communicating Gemini

This paper describes the design of Gemini a client program for SoccerServer. The goal of Gemini is learning cooperative behaviors without direct communication in multi-agent environment. With recent implementation, it can select the best strategy against opponent, statistically.

Difference and similarity of DNA sequence recognized by VDR homodimer and VDR/RXR heterodimer.

Nuclear receptors for the thyroid hormone and vitamin A and D cooperate with the retinoid X receptor (RXR) in activating the transcription. Although the hormone response elements for these receptors have been proposed in which spacing of the direct repeated motifs determine the specificity (so called 3-4-5 rule), vitamin D response elements (VDREs) in the natural context consist of often imperf...